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    1. Radiation Hormesis Debate
    2. The boosted defenses due to low-dose radiation would reduce the DNA damage and mutations
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    mohandoss99
    Dec 8, 2019
      ·  Edited: Feb 14, 2020

    The boosted defenses due to low-dose radiation would reduce the DNA damage and mutations

    A small amount of radiation (low-dose radiation) would cause a small amount of DNA damage which can result in mutations. However, DNA damage and mutations happen all the time even without radiation exposure, because of natural processes in our bodies, and this damage is much more than the damage that occurs due to low-dose radiation (Pollycove et al. 2003; Vilenchik et al. 2003).


    Our bodies respond to the small amount of damage from low-dose radiation by increasing defenses like antioxidants, DNA repair enzymes, immune system responses, apoptosis, etc. (Feinendegen et al. 2013).


    The boosted defenses would reduce the DNA damage and mutations during the subsequent period. The boosted defenses would also repair and reduce not only the damage caused by the low-dose radiation but also the naturally occurring DNA damage. The naturally occurring damage is much more than that caused by low-dose radiation (Pollycove et al. 2003; Vilenchik et al. 2003) and so the net result would be reduced DNA damage and mutations some time following the exposure to low-dose radiation (Osipov et al. 2013).


    References


    Feinendegen, L. E., M. Pollycove, et al. (2013). Hormesis by low dose radiation effects: Low-dose cancer risk modeling must recognize up-regulation of protection. Therapeutic Nuclear Medicine. R. P. Baum. Heidelberg, Springer: 789-805. http://link.springer.com/chapter/10.1007/174_2012_686


    Osipov, A. N., G. Buleeva, et al. (2013). "In vivo gamma-irradiation low dose threshold for suppression of DNA double strand breaks below the spontaneous level in mouse blood and spleen cells." Mutat Res 756(1-2): 141-145. http://www.ncbi.nlm.nih.gov/pubmed/23664857


    Pollycove, M. and L. E. Feinendegen (2003). "Radiation-induced versus endogenous DNA damage: possible effect of inducible protective responses in mitigating endogenous damage." Hum Exp Toxicol 22(6): 290-306. http://www.ncbi.nlm.nih.gov/pubmed/12856953


    Vilenchik, M. M. and A. G. Knudson (2003). "Endogenous DNA double-strand breaks: production, fidelity of repair, and induction of cancer." Proc Natl Acad Sci USA 100(22): 12871-12876. http://www.ncbi.nlm.nih.gov/pubmed/14566050



    1 comment
    0
    prismsuk
    Feb 16, 2020

    "...Though both radiation and folate deficiency caused DNA breaks, they affected the expression of different genes. Radiation activated excision and DNA double-strand break [DSB] repair genes and repressed mitochondrially encoded genes. Folate deficiency activated base and nucleotide excision repair genes and repressed folate-related genes. No DNA double-strand break repair gene was activated by folate deficiency..." ncbi.nlm.nih.gov/pubmed/14597554 I have limited knowledge of ionising radiation, but use this link to counter the 'dangers of radioactivity' nonsense I witness daily, by advising the overt, pathetic radiophobes to worry about folate deficiency and not a few extra mSv of radiation. To be able to state ionising radiation activates DSB repair genes, whereas folate deficiency does not, is a very powerful argument. I would appreciate links to a few more studies of 'agents' that cause DSBs but do not activate DSB repair genes. Do other such studies exist? Other dietary deficiencies that may be commonplace or widespread, along with common chemicals/toxins in the environment would be a most persuasive way to 'do battle'. IMHO, the study linked above could do much for the hormesis hypothesis in its own right, but many more studies, with the same potential may be 'out there'. I don't know how to get at them or assess them, but maybe you professionals might be able to do so.

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